基因名：
ADGRA2
产品别名：
GPR124； TEM5； ADGRA2； adhesion G protein-coupled receptor A2； adhesion G protein-coupled receptor A2； adhesion G protein-coupled receptor A2； G-protein coupled receptor 124； tumor endothelial marker 5； G蛋白偶联受体124； 物）； 肿瘤血管内皮标志物/G蛋白偶联受体124；
背景信息：
Tumor endothelial markers (TEMs) are abundantly expressed in the blood vessels of human solid tumors during angiogenesis and neoangiogensis. These include TEM1 (endosialin), TEM5 (G-protein coupled receptor 124) and TEM7 (plexin domain containing 1). TEMs are associated with the cell surface membrane at low levels in normal human and mouse tissues. TEM5 is a seven-pass transmembrane receptor, whereas TEM1, TEM7 and TEM8 span the membrane once. TEM5 expression is elevated during tumor angiogenesis and neoangiogenesis. TEM7 is highly expressed in tumor endothelium and neurons. Therefore, TEM5 and TEM7 may be suitable targets for the development of antiangiogenic therapies.
