基因名：
CNTNAP2
产品别名：
AUTS15； CASPR2； CDFE； NRXN4； PTHSL1； CNTNAP2； contactin associated protein 2； contactin associated protein 2； contactin-associated protein-like 2； cell recognition molecule Caspr2； contactin associated protein like 2； homolog of Drosophila neurexin IV； 接触蛋白关联蛋白样蛋白2(CNTNAP2)； 轴突相关CNTP2蛋白/少突胶质细胞；
背景信息：
CASPR is a transmembrane glycoprotein of the neurexin superfamily that is highly enriched in regions of myelinated axons. The axons of myelinated nerves in the adult nervous system possess specialized subcellular structures essential for efficient and rapid action potential propagation. CASPR and the closely related molecule CASPR2, a mammalian homolog of Drosophila Neurexin IV (Nrx-IV), demarcate distinct subdomains in myelinated axons. While CASPR is present at the paranodal junctions, CASPR2 is precisely colocalized with Shaker-like K+ channels in the juxtaparanodal region. CASPR2 specifically associates with Kv1.1, Kv1.2, and their Kvbeta2 subunit. CASPR family members may play a role in the local differentiation of the axon into distinct functional subdomains.
