基因名:
HERC4
产品别名:
HERC4; HECT and RLD domain containing E3 ubiquitin protein ligase 4; HECT and RLD domain containing E3 ubiquitin protein ligase 4; probable E3 ubiquitin-protein ligase HERC4; HECT domain and RCC1-like domain-containing protein 4; HECT-type E3 ubiquitin transferase HERC4; hect domain and RLD 4; HERC4 E3泛素蛋白连接酶;
背景信息:
HERC4 belongs to the HERC family of ubiquitin ligases, all of which contain a HECT domain and at least 1 RCC1 (MIM 179710)-like domain (RLD). The 350-amino acid HECT domain is predicted to catalyze the formation of a thioester with ubiquitin before transferring it to a substrate, and the RLD is predicted to act as a guanine nucleotide exchange factor for small G proteins (Hochrainer et al., 2005 [PubMed 15676274]).