基因名:
WIPI2
产品别名:
ATG18B; Atg21; CGI-50; IDDSSA; WIPI-2; WIPI2; WD repeat domain, phosphoinositide interacting 2; WD repeat domain, phosphoinositide interacting 2; WD repeat domain phosphoinositide-interacting protein 2; WD40 repeat protein interacting with phosphoinositides 2; WIPI49-like protein 2; 磷酸肌醇2;
背景信息:
WD40 repeat proteins are key components of many essential biologic functions. They regulate the assembly of multiprotein complexes by presenting a beta-propeller platform for simultaneous and reversible protein-protein interactions. Members of the WIPI subfamily of WD40 repeat proteins, such as WIPI2, have a 7-bladed propeller structure and contain a conserved motif for interaction with phospholipids (Proikas-Cezanne et al., 2004 [PubMed 15602573]).[supplied by OMIM, Mar 2008]