基因名：
Cop1
产品别名：
AI316802； C80879； Rfwd2； Cop1； COP1, E3 ubiquitin ligase； COP1, E3 ubiquitin ligase； E3 ubiquitin-protein ligase COP1； E3 ubiquitin-protein ligase RFWD2； RING finger and WD repeat domain protein 2； RING-type E3 ubiquitin transferase RFWD2； constitutive photomorphogenesis protein 1 homolog； constitutive photomorphogenic protein 1； mCOP1； ring finger and WD repeat domain 2； E3泛素蛋白连接酶COP1； 磷酸化E3泛素蛋白连接酶COP1；
背景信息：
COP1 is an E3 ubiquitin ligase protein that mediates ubiquitination and degradation of target proteins such as c-Jun and p53. It is a component of the DCX DET1-COP1 ubiquitin ligase complex which consists of RBX1, DET1, DDB1, CUL4A and COP1. Localizing to the cytoplasm and to the nucleus, COP1 is primarily expressed in testis, placenta, heart and skeletal muscle. COP1 is a potent inhibitor of p53-dependent transcription and apoptosis but, when phosphorylated by Atm (ataxia telangiectasia mutated) in response to DNA damage, the COP1-p53 complex is disrupted and p53 is allowed to exert its pro-apoptotic properties. In ovarian and breast cancers, COP1 is overexpressed, suggesting a role for COP1 in tumorigenesis.
