基因名：
LYPD3
产品别名：
C4.4A； LYPD3； LY6/PLAUR domain containing 3； LY6/PLAUR domain containing 3； ly6/PLAUR domain-containing protein 3； 2310061G07Rik； GPI-anchored metastasis-associated protein C4.4A homolog； GPI-anchored metastasis-associated protein homolog； MIG-C4； matrigel-induced gene C4 protein； LYPD3蛋白；
背景信息：
Ly6/PLAUR domain containing3 (LYPD-3) is a GPI-linked protein. The structure of LYPD-3 is similar to the urokinasetype plasminogen activator receptor (uPAR). LYPD-3 is a 6 -100 kDa molecule with variable cell type-specific N-O-linked glycosylation, mature human LYPD-3 contains two uPAR/Ly6 domains and a Ser/Thr/Pro-rich (STP) region includes a protease sensitive site . The interaction of LYPD-3 with Laminin 1 and 5 on neighboring cells promotes the adhesion, spreading, and migration of tumor cells. LYPD-3 additionally interacts with Galectin-3 and the anterior gradient proteins AG-2 and AG-3. LYPD-3 overexpression in non-small cell lung cancer is predictive of increased mortality.
