基因名：
IL37
产品别名：
FIL1； FIL1(ZETA)； FIL1Z； IL-1F7； IL-1H； IL-1H4； IL-1RP1； IL-23； IL-37； IL1F7； IL1H4； IL1RP1； IL37； interleukin 37； interleukin 37； interleukin-37； FIL1 zeta； IL-1 zeta； IL-1F7b (IL-1H4, IL-1H, IL-1RP1)； IL-1X protein； IL1F7 (canonical product IL-1F7b)； interleukin 1 family member 7； interleukin 1, zeta； interleukin-1 homolog 4； interleukin-1 superfamily z； interleukin-1-related protein； interleukin-23； 白细胞介素37；
背景信息：
Decreasing synthesis of IL-37 in PBMCs will cause increasing production of pro-inflammatory cytokines such as IL-1 alpha, IL-1 beta, IL-6 and TNF- alpha. The IL-37 work as an innate inflammatory inhibitor is also proved by its high expression in synovial tissue from rheumatoid arthritis patients. Full length IL-37 locates mainly in the cytoplasm, and it can translocate to the nucleus after activation through cleavage by CASP1, then exerts its activity by directly interacting with SMAD3.
