基因名：
LSM1
产品别名：
CASM； YJL124C； LSM1； LSM1 homolog, mRNA degradation associated； LSM1 homolog, mRNA degradation associated； U6 snRNA-associated Sm-like protein LSm1； LSM1 homolog, U6 small nuclear RNA associated； LSM1 mRNA degradation associated； LSM1, U6 small nuclear RNA associated； LSM1-like protein U6 small nuclear RNA associated； cancer-associated Sm protein； cancer-associated Sm-like protein； small nuclear ribonuclear CaSm；
背景信息：
U6 snRNA-Associated Sm-Like Protein LSm1 (LSM1) belongs to the snRNP Sm proteins family. The Sm-like proteins are thought to form a stable heteromer present in tri-snRNP particles, which plays an important role in pre-mRNA splicing. LSM1 binds specifically to the 3-terminal U-tract of U6snRNA. LSM1 can interact with SLBP when histone mRNA is being rapidly degraded during the S phase. In addition, LSM1 is associated with cellular transformation and the progression of several malignancies including mesothelioma, lung cancer and breast cancer.
