基因名：
Tnfrsf12a
产品别名：
AI255180； C87282； Fn14； HPIP； TWEAK-R； TweakR； Tnfrsf12a； tumor necrosis factor receptor superfamily, member 12a； tumor necrosis factor receptor superfamily, member 12a； tumor necrosis factor receptor superfamily member 12A； FGF-inducible 14； fibroblast growth factor-inducible immediate-early response protein 14； fibroblast growth factor-regulated protein 2； tweak-receptor； type I transmembrane protein Fn14； 肿瘤坏死因子受体超家族成员12A(TNFRSF12A)； 肿瘤坏死因子配体超家族成员12A；
背景信息：
Tumor necrosis factor receptor superfamily member 12A(TNFRSF12A) is also known as Fibroblast growth factor-inducible immediate-early response protein 14, FN14, CD266 antigen and tweak-receptor. TNFRSF12A is a single-pass type I membrane protein, including a 27 aa signal peptide, a 53 aa extracellular domain, a 21 aa transmembrane domain and a 28 aa cytoplasmic domain. TNFRSF12A is highly expressed in heart, placenta and kidney. TNFRSF12A can be induced by FGF1 and phorbol ester. TNFRSF12A binds to TWEAK/TNFSF12A to initiate a signal transduction cascade, causing different cellular responses such as cell death, cell proliferation, and angiogenesis.
