基因名：
UBE2S
产品别名：
E2-EPF； E2EPF； EPF5； UBE2S； ubiquitin conjugating enzyme E2 S； ubiquitin conjugating enzyme E2 S； ubiquitin-conjugating enzyme E2 S； E2 ubiquitin-conjugating enzyme S； E2-EPF5； ubiquitin carrier protein S； ubiquitin conjugating enzyme E2S； ubiquitin-conjugating enzyme E2-24 kDa； ubiquitin-conjugating enzyme E2-EPF5； ubiquitin-protein ligase S； 泛素交联酶； 泛素结合酶E2C结合蛋白E2S(UBE2S)；
背景信息：
Ubiquitin-Conjugating Enzyme E2 S (UBE2S) is a member of the Ubiquitin-Conjugating Enzyme family. UBE2S interacts with CDC20, FZR1/CDH1 and VHL. UBE2S can form a thiol ester linkage with Ubiquitin in an Ubiquitin Activating Enzyme-Dependent manner, a characteristic property of Ubiquitin Carrier Proteins. UBE2S acts as an essential factor of the Anaphase Promoting Complex/Cyclosome, a cell cycle-regulated Ubiquitin ligase that controls progression through mitosis. UBE2S is also involved in ubiquitination and subsequent degradation of VHL, resulting in an accumulation of HIF1A.
