基因名：
DCPS
产品别名：
ARS； DCS1； HINT-5； HINT5； HSL1； HSPC015； DCPS； decapping enzyme, scavenger； decapping enzyme, scavenger； m7GpppX diphosphatase； 5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase； decapping scavenger enzyme； epididymis secretory sperm binding protein； heat shock-like protein 1； hint-related 7meGMP-directed hydrolase； histidine triad nucleotide-binding protein 5； histidine triad protein member 5； homolog of C. elegans 7meGMP-directed hydrolase dcs-1； mRNA decapping enzyme； scavenger mRNA-decapping enzyme DcpS； 清道夫脱帽酶/热休克蛋白1；
背景信息：
Eukaryotic cells primarily utilize exoribonucleases and decapping enzymes to degrade their mRNA. DcpS is a scavenger pyrophosphatase that hydrolyzes the residual cap structure following 3' to 5' decay of an mRNA. Following mRNA degradation DcpS releases N-7 methyl guanosine monophosphate and 5'-diphosphate terminated cap or mRNA products. The central histidine within the DcpS HIT motif is critical for decapping activity and defines the HIT motif as a new mRNA decapping domain, making DcpS the first member of the HIT family of proteins with a defined biological function. HIT proteins are homodimeric and contain two conserved 100-amino-acid HIT fold domains with independent active sites that are each sufficient to bind and hydrolyze cognate substrates.
