基因名：
MYLIP
产品别名：
IDOL； MIR； MYLIP； myosin regulatory light chain interacting protein； myosin regulatory light chain interacting protein； E3 ubiquitin-protein ligase MYLIP； E3 ubiquitin ligase-inducible degrader of the low density lipoprotein receptor； RING-type E3 ubiquitin transferase MYLIP； band 4.1 superfamily member BZF1； cellular modulator of immune recognition (c-MIR)； inducible degrader of the LDL-receptor； 低密度脂蛋白受体的诱导降解蛋白；
背景信息：
E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of myosin regulatory light chain (MRLC), LDLR, VLDLR and LRP8. Proteasomal degradation of MRLC leads to inhibit neurite outgrowth in presence of NGF by counteracting the stabilization of MRLC by saposin-like protein (CNPY2/MSAP) and reducing CNPY2-stimulated neurite outgrowth. Acts as a sterol-dependent inhibitor of cellular cholesterol uptake by mediating ubiquitination and subsequent degradation of LDLR.
