基因名：
ICOS
产品别名：
AILIM； CD278； CVID1； ICOS； inducible T cell costimulator； inducible T cell costimulator； inducible T-cell costimulator； activation-inducible lymphocyte immunomediatory molecule； inducible T-cell co-stimulator； inducible costimulator； ICOS蛋白； T-细胞可诱导共刺激分子(ICOS)； 诱导协同刺激分子CD278；
背景信息：
Inducible T-cell costimulator, also known as activation-inducible lymphocyte immunomediatory molecule, CD278, AILIM, CVID1 and ICOS, belongs to the CD28 and CTLA4 cell surface receptor family.. ICOS contains one Ig-like V-type domain and exsits as a homodimer with disulfide-linked. ICOS is highly expressed on tonsillar T-cellsand can be induced by PMA and ionomycin, ICOS plays an important role in cell-cell signaling, immune responses, and regulation of cell proliferation. Defects in ICOS are the cause of immunodeficiency common variable type 1, which is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antige
