基因名：
Uba5
产品别名：
CG1749； Dmel\CG1749； MoeB； dMoaD； dUBA5； Uba5； Ubiquitin-like activating enzyme 5； Ubiquitin-like activating enzyme 5； Ubiquitin-like activating enzyme 5； CG1749-PA； Uba5 homologue； Uba5-PA； ubiquitin activating enzyme 5； 泛素样修饰激活酶5(UBA5)；
背景信息：
UBA5 is a member of the ubiquitin-activating E1 family and UBA5 subfamily. Ubiquitin and ubiquitin-like proteins are recognized as covalently conjugated to various cellular substrates by a three-step enzymatic pathway. The ubiquitin-activating enzyme (E1) has a vital role in the first step of ubiquitination pathway to activate ubiquitin or ubiquitin-like proteins. UBA5 activates ubiquitin-fold modifier 1, a ubiquitin-like post-translational modifier protein, via the formation of a high-energy thioester bond. UBA5 is located primarily in cytoplasm, while it generally localizes to the nucleus in presence of SUMO2.
