基因名：
CRNN
产品别名：
C1orf10； DRC1； PDRC1； SEP53； CRNN； cornulin； cornulin； cornulin； 53 kDa putative calcium-binding protein； 53 kDa squamous epithelial-induced stress protein； 58 kDa heat shock protein； squamous epithelial heat shock protein 53； tumor-related protein； Cornulin蛋白(CRNN)； 热休克蛋白58；
背景信息：
Cornulin is a member of the fused gene family of molecular chaperones. Human Cornulin contains N-terminus EF-hand domains and Ca2+ binding domains, and two glutamine- and threonine-rich 60 amino acid repeats in its C-terminus. Cornulin involves in the mucosal/epithelial immune response and epidermal differentiation. Cornulin is a survival factor that participates in the clonogenicity of squamous esophageal epithelium cell lines, attenuates deoxycholic acid (DCA)-induced apoptotic cell death and release of calcium. When Cornulin is overexpressed in oral squamous carcinoma cell lines, it regulates negatively cell proliferation by the induction of G1 arrest.
