基因名:
Fis1
产品别名:
BcDNA:RE29957; CG17510; Dmel\CG17510; FIS1; NEST:bs15a08; bs15a08.y1; dFis1; fis1; Fis1; Fission, mitochondrial 1; Fission, mitochondrial 1; Fission, mitochondrial 1; CG17510-PA; CG17510-PC; CG17510-PD; CG17510-PE; CG17510-PF; CG17510-PG; Fis1-PA; Fis1-PC; Fis1-PD; Fis1-PE; Fis1-PF; Fis1-PG; Fission 1蛋白(FIS1); 线粒体裂变1蛋白;
背景信息:
Mitochondrial Fission 1 Protein (FIS1) is a member of the FIS1 family. FIS1 is a single-pass membrane protein and contains one TPR repeat. FIS1 is part of the mitochondrial complex that promotes mitochondrial fission. FIS1 can induce cytochrome C discharge from the mitochondrion to the cytosol, eventually leading to apoptosis. In addition, FIS1 participates in peroxisomal growth and division. The C-terminus of FIS1 is required for mitochondrial or peroxisomal localization, while the N-terminus is necessary for mitochondrial or peroxisomal fission, localization and regulation of the interaction with DNM1L.