基因名：
EXOSC3
产品别名：
CGI-102； PCH1B； RRP40； Rrp40p； bA3J10.7； hRrp-40； p10； EXOSC3； exosome component 3； exosome component 3； exosome complex component RRP40； exosome complex exonuclease RRP40； ribosomal RNA-processing protein 40； 核糖体RNA合成蛋白40；
背景信息：
The exosome is a multisubunit complex of 3’ to 5’ exoribonucleases. It is involved in a variety of cellular processes and is responsible for degrading unstable mRNAs that contain AU-rich elements in their untranslated 3’ region. EXOSC3 (exosome component 3), also known as p10, CGI-102, RRP40 (Ribosomal RNA-processing protein 40), Rrp40p or hRrp40p, is a component of the exosome multienzyme ribonuclease complex. Localizing to the cytoplasm and nucleolus, EXOSC3 contains a putative S1 RNA-binding domain and is capable of binding RNA. EXOSC3 is a component of the top cap of the exosome and is essential for exosome stability. In addition, EXOSC3 is required for the processing of the 7S pre-RNA to the mature 5.8S rRNA.
