基因名:
EGFL7
产品别名:
NEU1; VE-STATIN; ZNEU1; EGFL7; EGF like domain multiple 7; EGF like domain multiple 7; epidermal growth factor-like protein 7; EGF-like protein 7; NOTCH4-like protein; multiple EGF-like domains protein 7; multiple epidermal growth factor-like domains protein 7; vascular endothelial statin; EGF样域蛋白7(EGFL7); 类表皮生长因子域7;
背景信息:
EGFL7 (EGF-like domain-containing protein 7) regulates vascular tubulogenesis in vivo. During sprouting angiogenesis, groups of endothelial cells (ECs) migrate together in units called sprouts. EGFL7 regulates the proper spatial organization of ECs within each sprout and influences their collective movement. It inhibits platelet-derived growth factor (PDGF)-BB-induced smooth muscle cell migration and promotes endothelial cells adhesion to the substrate in vitro.