基因名：
ZDHHC2
产品别名：
DHHC2； ZNF372； ZDHHC2； zinc finger DHHC-type palmitoyltransferase 2； zinc finger DHHC-type palmitoyltransferase 2； palmitoyltransferase ZDHHC2； DHHC-2； acyltransferase ZDHHC2； ream； rec； reduced expression associated with metastasis protein； reduced expression in cancer protein； testis tissue sperm-binding protein Li 56e； zinc finger DHHC domain-containing protein 2； zinc finger DHHC-type containing 2； zinc finger protein 372； zinc finger, DHHC domain containing 2； 锌指蛋白372；
背景信息：
ZDHHC2 is a 367 amino acid multi-pass membrane protein that contains one DHHC-type zinc finger. The ubiquitously expressed ZDHHC2 protein functions as a palmitoyltransferase that uses palmitoyl-CoA and catalyzes the conversion of target proteins, namely GAP-43 and PSD-95, to S-palmitoyl proteins. Defects in the gene encoding ZDHHC2 are found in colorectal cancer and hepatocellular carcinoma, suggesting a role for ZDHHC2 in tumorigenesis. The gene encoding human ZDHHC2 maps to chromosome 8, which consists of nearly 146 million base pairs, houses more than 800 genes and is associated with a variety of diseases and malignancies.
