基因名：
TAOK3
产品别名：
DPK； JIK； MAP3K18； hKFC-A； TAOK3； TAO kinase 3； TAO kinase 3； serine/threonine-protein kinase TAO3； CTCL-associated antigen HD-CL-09； JNK/SAPK-inhibitory kinase； STE20-like kinase； cutaneous T-cell lymphoma-associated antigen HD-CL-09； dendritic cell-derived protein kinase； jun kinase-inhibitory kinase； kinase from chicken homolog A； thousand and one amino acid protein 3； JNK/ SAPK抑制激酶；
背景信息：
JNK/SAPK-inhibitory kinase (JIK) is a serine/threonine kinase that belongs to the STE20 kinase family. The kinase domain of JIK is similar to the GCK-like subfamily of STE20 kinases, while its non-catalytic domain is similar to a Caenorhabditis elegans putative serine/threonine kinase, SULU. JIK inhibits c-Jun NH2-terminal kinase/stress-activated protein kinase (JNK/SAPK), which is activated by many types of cellular stresses and extracellular signals. JNK/SAPK regulates cell survival, apoptosis and proliferation in mouse development. JIK is negatively regulated by epidermal growth factor (EGF) and tyrosine kinase receptors. In unstimulated human T cells, JIK is cytoplasmic, whereas in the continuously dividing human T cells of Jurkat lymphoma, JIK is nuclear.
