基因名：
UBR5
产品别名：
DD5； EDD； EDD1； HYD； UBR5； ubiquitin protein ligase E3 component n-recognin 5； ubiquitin protein ligase E3 component n-recognin 5； E3 ubiquitin-protein ligase UBR5； E3 identified by differential display； E3 ubiquitin-protein ligase, HECT domain-containing 1； HECT-type E3 ubiquitin transferase UBR5； hyperplastic discs protein homolog； progestin-induced protein； E3泛素蛋白连接酶EDD；
背景信息：
EDD is a progestin-regulated gene that was isolated from T-47D human breast cancer cells. Based on sequence homology, EDD appears to be a human homolog of the Drosophila hyperplastic discs (hyd) gene, a tumor suppressor gene that is required for control of imaginal disc growth. EDD contains a HECT domain in the carboxy terminus. HECT domain-containing proteins function as ubiquitin-protein ligases, or E3 enzymes. EDD has been shown to bind to ubiquitin, and like other HECT family proteins, may function as an E3 ubiquitin-protein ligase.
