重组ETS1相关蛋白2

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重组ETS1相关蛋白2

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

Recombinant TDP2
Recombinant tyrosyl-DNA phosphodiesterase 2 protein

基因名：

TDP2

产品别名：

AD022； EAP2； EAPII； TTRAP； dJ30M3.3； hTDP2； TDP2； tyrosyl-DNA phosphodiesterase 2； tyrosyl-DNA phosphodiesterase 2； tyrosyl-DNA phosphodiesterase 2； 5'-Tyr-DNA phosphodiesterase； 5'-tyrosyl-DNA phosphodiesterase； ETS1-associated protein 2； ETS1-associated protein II； TRAF and TNF receptor-associated protein； VPg unlinkase； epididymis secretory sperm binding protein； tyr-DNA phosphodiesterase 2； tyrosyl-RNA phosphodiesterase； ETS1相关蛋白2；

背景信息：

DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 5'-phosphodiester bond, giving rise to DNA with a free 5' phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase 2 (TOP2) active site tyrosine residue. Hydrolyzes 5'-phosphoglycolates on protruding 5' ends on DNA double-strand breaks (DSBs) due to DNA damage by radiation and free radicals. The 5'-tyrosyl DNA phosphodiesterase activity can enable the repair of TOP2-induced DSBs without the need for nuclease activity, creating a 'clean' DSB with 5'-phosphate termini that are ready for ligation. Has also 3'-tyrosyl DNA phosphodiesterase activity, but less efficiently and much slower than TDP1. May also act as a negative regulator of ETS1 and may inhibit nuclear factor-kappa-B activation.

标签：His-tag
分类：Recombinant
类型：Protein
偶联物：Unconjugated
内毒素水平：按批次，参阅瓶身标签
性状:Liquid
浓度：Batch dependent (Please refer to the vial label for the specific concentration.)
纯化类型：purified
内含物：不含防腐剂
应用:Positive Control;Immunogen;SDS-PAGE;WB.
储存：2-8°C不超过一个月，-80°C不超过12个月。避免反复冻融。
注意事项：仅供实验室使用。不适用于人类或动物的任何临床，治疗或诊断用途。不适合动物或人类食用。