基因名：
TDP2
产品别名：
AD022； EAP2； EAPII； TTRAP； dJ30M3.3； hTDP2； TDP2； tyrosyl-DNA phosphodiesterase 2； tyrosyl-DNA phosphodiesterase 2； tyrosyl-DNA phosphodiesterase 2； 5'-Tyr-DNA phosphodiesterase； 5'-tyrosyl-DNA phosphodiesterase； ETS1-associated protein 2； ETS1-associated protein II； TRAF and TNF receptor-associated protein； VPg unlinkase； epididymis secretory sperm binding protein； tyr-DNA phosphodiesterase 2； tyrosyl-RNA phosphodiesterase； ETS1相关蛋白2；
背景信息：
DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 5'-phosphodiester bond, giving rise to DNA with a free 5' phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase 2 (TOP2) active site tyrosine residue. Hydrolyzes 5'-phosphoglycolates on protruding 5' ends on DNA double-strand breaks (DSBs) due to DNA damage by radiation and free radicals. The 5'-tyrosyl DNA phosphodiesterase activity can enable the repair of TOP2-induced DSBs without the need for nuclease activity, creating a 'clean' DSB with 5'-phosphate termini that are ready for ligation. Has also 3'-tyrosyl DNA phosphodiesterase activity, but less efficiently and much slower than TDP1. May also act as a negative regulator of ETS1 and may inhibit nuclear factor-kappa-B activation.
