SIB-1893 is a highly selective non-competitive antagonist for the metabotropic glutamate mGlu5 receptor subtype; exhibits an IC50 of 0.3 μM at hmGlu5, compared with > 100 μM at hmGlu1b, hmGlu2, hmGlu6, hmGlu7 and hmGlu8. It positive allosteric modulator at mGlu4 receptors. References: Luszczki JJ, Borowicz KK, Czuczwar SJ. Non-competitive metabotropic glutamate subtype 5 receptor antagonist (SIB-1893) decreases body temperature in rats. Pharmacol Rep. 2005 Nov-Dec;57(6):795-801. PubMed PMID: 16382199.

纯度：≥98%

CAS：7370-21-0