基因名:
Nit2
产品别名:
1190017B19Rik; D16Ertd502e; Nit2; nitrilase family, member 2; nitrilase family, member 2; omega-amidase NIT2; Nit protein 2; nitrilase homolog 2; NIT2蛋白;
背景信息:
[FUNCTION] Has a omega-amidase activity. The role of omega-amidase is to remove potentially toxic intermediates by converting alpha-ketoglutaramate and alpha-ketosuccinamate to biologically useful alpha-ketoglutarate and oxaloacetate, respectively. Overexpression decreases the colony-forming capacity of cultured cells by arresting cells in the G2 phase of the cell cycle. [SUBUNIT] Homodimer. [SUBCELLULAR LOCATION] Cytoplasm. [TISSUE SPECIFICITY] Detected in fetal brain (at protein level). Ubiquitous. Detected in heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, prostate, spleen, thymus, prostate, testis, ovary, small intestine and colon. [SIMILARITY] Belongs to the UPF0012 family.