基因名：
Hif3a
产品别名：
Ipas； MOP7； NEPAS； bHLHe17； Hif3a； hypoxia inducible factor 3, alpha subunit； hypoxia inducible factor 3, alpha subunit； hypoxia-inducible factor 3-alpha； HIF-3-alpha； HIF3-alpha； HIF3-alpha-1； basic-helix-loop-helix-PAS protein MOP7； hypoxia inducible factor three alpha； inhibitory PAS domain protein； member of PAS protein 7； neonatal and embryonic PAS protein； 缺氧诱导因子3α/HIF-3α；
背景信息：
Hypoxia-inducible factor (HIF) is one of the most important factors in the cellular response to hypoxia, transcriptionally activating genes encoding proteins that mediate adaptive responses to reduced oxygen availability. HIF is a heterodimer consisting of one of three subunits, HIF1 alpha, HIF2 alpha, or HIF3 alpha. HIF target genes play critical roles in metabolism, angiogenesis, cell proliferation and cell survival. HIF3 alpha protein is one of several alpha/beta-subunit heterodimeric transcription factors that regulate many adaptive responses to low oxygen tension (hypoxia). The alpha 3 subunit lacks the transactivation domain found in factors containing either the alpha 1 or alpha 2 subunits. HIF3 alpha may be a marker for tumor growth and angiogenesis.
