基因名：
S1PR5
产品别名：
EDG8； Edg-8； S1P5； SPPR-1； SPPR-2； S1PR5； sphingosine-1-phosphate receptor 5； sphingosine-1-phosphate receptor 5； sphingosine 1-phosphate receptor 5； S1P receptor 5； S1P receptor Edg-8； endothelial differentiation G-protein-coupled receptor 8； endothelial differentiation, sphingolipid G-protein-coupled receptor, 8； sphingosine 1-phosphate receptor EDG8； sphingosine 1-phosphate receptor Edg-8； 内皮细胞分化G蛋白偶联受体8；
背景信息：
The EDG (endothelial differentiation gene) family of G protein coupled receptors consists of eight family members that bind lysophospholipid (LPL) mediators, including sphingosine-1-phosphate (SPP) and lysophosphatidic acid (LPA). EDG-1, EDG-3, EDG-5 (also designated H218 and AGR16) and EDG-8 bind SPP with high affinity. EDG-6 is a low affinity receptor for SPP. LPA preferentially binds to EDG-2, EDG-4 and EDG-7. The EDG receptors couple to multiple G proteins to signal through Ras, MAP kinase, Rho, Phospholipase C or other tyrosine kinases, which lead to cell survival, growth, migration and differentiation. EDG-1 signals through Gi proteins to activate Akt and is expressed in glioma cells. EDG-2 is expressed in brain, especially in white matter tract regions, while EDG-3 is expressed in cardiovascular tissue and in cerebellum. EDG-4 is highly expressed on leukocytes and brain, and EDG-5 has wide tissue distribution, including cardiovascular tissue and brain. EDG-6, which is expressed in lymphoid and hematopoietic tissues and in lung, signals through Gi/o proteins, which activate growth related pathways.
