重组β淀粉样蛋白前体结合蛋白B-1

首页蛋白库基因库产品会员服务

位置：首页 > 产品库 > 重组β淀粉样蛋白前体结合蛋白B-1

立即咨询

重组β淀粉样蛋白前体结合蛋白B-1

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

重组淀粉样蛋白β前体蛋白结合蛋白B1相互作用蛋白(APBB1IP)
Recombinant APBB1IP

基因名：

APBB1IP

产品别名：

INAG1； PREL1； RARP1； RIAM； APBB1IP； amyloid beta precursor protein binding family B member 1 interacting protein； amyloid beta precursor protein binding family B member 1 interacting protein； amyloid beta A4 precursor protein-binding family B member 1-interacting protein； APBB1-interacting protein 1； MLLT10/APBB1IP reciprocal fusion； MLLT10/APBB1IP reciprocal fusion protein； PREL-1； RARP-1； Rap1-GTP-interacting adaptor molecule； Rap1-interacting adaptor molecule； proline rich EVH1 ligand 1； proline-rich protein 73； rap1-GTP-interacting adapter molecule； retinoic acid-responsive proline-rich protein 1； β淀粉样蛋白前体结合蛋白B-1；淀粉样蛋白β前体蛋白结合蛋白B1相互作用蛋白(APBB1IP)；

背景信息：

APBB1IP is a 666 amino acid protein that contains one PH domain, one Ras-associating domain and belongs to the MRL family. Encoded by a gene that maps to human chromosome 10p12.1, APBB1IP likely functions in signal transduction from Ras activation to Actin cytoskeletal remodeling. APBB1IP also suppresses insulin-induced promoter activities, by way of SRE and AP1. The two proline-rich regions of APBB1IP are necessary for AP1 transcription suppression. Ubiquitously expressed, with high expression in thymus, spleen, lymph node, bone marrow and peripheral leukocytes, APBB1IP is induced by all-trans-retinoic acid (ATRA) and mediates Rap 1-induced adhesion. APBB1IP also interacts with RAP 1A, Profilin-1, VASP and Mena.