基因名:
HAUS6
产品别名:
Dgt6; FAM29A; HAUS6; HAUS augmin like complex subunit 6; HAUS augmin like complex subunit 6; HAUS augmin-like complex subunit 6; dim gamma-tubulin homolog; family with sequence similarity 29, member A; FAM29蛋白;
背景信息:
The human augmin complex (HAUS) is an evolutionarily conserved 8-subunit protein complex that was initially discovered in Drosophila. The HAUS complex is essential for microtubule generation, centrosome integrity, mitotic spindle assembly and completion of cytokinesis. HAUS6 (HAUS augmin-like complex, subunit 6), also known as FAM29A or Dgt6, is a 955 amino acid component of the augmin complex. Required for mitotic progression, HAUS6 localizes to cytoplasm, cytoskeleton, mitotic spindle microtubules and interphase centrosomes, and undergoes post-translational phosphorylation following mitosis on multiple serine and threonine residues. HAUS6 exists as two alternatively spliced isoforms that are encoded by a gene located on human chromosome 9.