基因名：
RNF43
产品别名：
RNF124； SSPCS； URCC； RNF43； ring finger protein 43； ring finger protein 43； E3 ubiquitin-protein ligase RNF43； RING-type E3 ubiquitin transferase RNF43； 环指蛋白43；
背景信息：
RNF43 (E3 ubiquitin-protein ligase RNF43 or RING-type E3 ubiquitin transferase RNF43) functions as a tumor suppressor, by exerting a predominant negative feedback mechanism in the Wnt/β-catenin signaling pathway. RNF43 inhibits Wnt/beta-catenin signaling by ubiquitinating Frizzled receptor and targeting it to the lysosomal pathway for degradation.
