基因名：
RNF31
产品别名：
HOIP； Paul； ZIBRA； RNF31； ring finger protein 31； ring finger protein 31； E3 ubiquitin-protein ligase RNF31； HOIL-1-interacting protein； RING-type E3 ubiquitin transferase RNF31； zinc in-between-RING-finger ubiquitin-associated domain protein； 环指蛋白31；
背景信息：
E3 ubiquitin-protein ligase component of the LUBAC complex which conjugates linear polyubiquitin chains in a head-to-tail manner to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation. LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways. Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation. LUBAC is proposed to be recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex. Binds polyubiquitin of different linkage types.
