基因名：
ARHGAP17
产品别名：
MST066； MST110； MSTP038； MSTP066； MSTP110； NADRIN； PP367； PP4534； RICH-1； RICH1； WBP15； ARHGAP17； Rho GTPase activating protein 17； Rho GTPase activating protein 17； rho GTPase-activating protein 17； RhoGAP interacting with CIP4 homologs 1； neuron-associated developmentally regulated protein； rho-type GTPase-activating protein 17； Rho GTP酶激活蛋白17(ARHGAP17)； 神经细胞发育相关调控蛋白；
背景信息：
ARHGAP17 is a Rho GTPase-activating protein involved in the maintenance of tight junction by regulating the activity of CDC42, thereby playing a central role in apical polarity of epithelial cells. It specifically acts as a GTPase activator for the CDC42 GTPase by converting it to an inactive GDP-bound state. The complex formed with AMOT acts by regulating the uptake of polarity proteins at tight junctions, possibly by deciding whether tight junction transmembrane proteins are recycled back to the plasma membrane or sent elsewhere. RHGAP17 participates in the Ca(2+)-dependent regulation of exocytosis, possibly by catalyzing GTPase activity of Rho family proteins and by inducing the reorganization of the cortical actin filaments. Acts as a GTPase activator in vitro for RAC1.
