基因名：
THAP1
产品别名：
DYT6； THAP1； THAP domain containing 1； THAP domain containing 1； THAP domain-containing protein 1； 4833431A01Rik； THAP domain containing, apoptosis associated protein 1； THAP domain protein 1； nuclear proapoptotic factor； 核凋亡因子THAP1；
背景信息：
THAP1 contains a THAP domain, a zinc-dependent DNA-binding domain. It colocalizes with the apoptosis response protein PAWR/PAR-4 in promyelocytic leukemia (PML) nuclear bodies and is a pro-apoptopic protein that potentiates both serum-withdrawal and TNF-induced apoptosis. It is a physiologic regulator of endothelial cell proliferation and cell-cycle progression, two essential processes for angiogenesis.
