基因名：
RCBTB1
产品别名：
CLLD7； CLLL7； GLP； RDEOA； RCBTB1； RCC1 and BTB domain containing protein 1； RCC1 and BTB domain containing protein 1； RCC1 and BTB domain-containing protein 1； CLL deletion region gene 7 protein； GDP/GTP exchange factor (GEF)-like protein； chronic lymphocytic leukemia deletion region gene 7 protein； regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1； regulator of chromosome condensation and BTB domain-containing protein 1； 鸟嘌呤核苷酸交换因子； 鸟嘌呤核苷酸交换因子CLLD7；
背景信息：
The BTB domain, also known as the POZ (poxvirus and zinc finger) domain, is an N-terminal homodimerization domain that contains multiple copies of kelch repeats and/or C2H2-type zinc fingers. Proteins that contain BTB domains are thought to be involved in transcriptional regulation via control of chromatin structure and function. RCBTB1 (regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1), also known as GLP, CLLD7, CLLL7 or E4.5, is a 531 amino acid protein that localizes to the nucleus and contains two BTB (POZ) domains and six RCC1 repeats. Expressed ubiquitously, RCBTB1 is thought to be involved in cell cycle regulation, specifically via chromatin remodeling. The gene encoding RCBTB1 maps to a region on human chromosome 13 that is frequently deleted in B-cell chronic lymphocytic leukemia, suggesting a possible role for RCBTB1 in tumor suppression.
