基因名：
GIMAP5
产品别名：
HIMAP3； IAN-5； IAN4； IAN4L1； IAN5； IMAP3； IROD； NCPH2； GIMAP5； GTPase, IMAP family member 5； GTPase, IMAP family member 5； GTPase IMAP family member 5； immune associated nucleotide 4 like 1； immune-associated nucleotide-binding protein 5； immunity associated protein 3； immunity-associated nucleotide 5 protein； inhibitor of radiation- and OA-induced apoptosis, Irod/Ian5； GTP酶IMAP家族成员5；
背景信息：
GIMAP5, also known as IAN5, IAN4L1 (immunity-associated nucleotide 4-like 1 protein), IAN4, IMAP3, HIMAP3 or IROD, is a 307 amino acid single-pass type IV membrane protein of the mitochondrial outer membrane. A member of the GTP-binding superfamily and the immuno-associated nucleotide (IAN) subfamily, GIMAP5 plays a role in T-cell survival and mitochondrial integrity. GIMAP5 is highly expressed in CD4 and CD8-positive T-cells and monocytes, as well as B-lymphocyte-derived neoplasms. GIMAP5 exists as two alternatively spliced isoforms and is encoded by a gene that maps to human chromosome 7q36.1. Defects in the GIMAP5 gene are associated with systemic lupus erythematosus.
