基因名：
RBM38
产品别名：
HSRNASEB； RNPC1； SEB4B； SEB4D； dJ800J21.2； RBM38； RNA binding motif protein 38； RNA binding motif protein 38； RNA-binding protein 38； CLL-associated antigen KW-5； RNA-binding region (RNP1, RRM) containing 1； RNA-binding region-containing protein 1； ssDNA-binding protein SEB4； RNA结合基元蛋白38(RBM38)； RNA结合蛋白38；
背景信息：
RNA-binding protein that specifically bind the 3'-UTR of CDKN1A transcripts, leading to maintain the stability of CDKN1A transcripts, thereby acting as a mediator of the p53/TP53 family to regulate CDKN1A. CDKN1A is a cyclin-dependent kinase inhibitor transcriptionally regulated by the p53/TP53 family to induce cell cycle arrest. Isoform 1, but not isoform 2, has the ability to induce cell cycle arrest in G1 and maintain the stability of CDKN1A transcripts induced by p53/TP53. Also acts as a mRNA splicing factor. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Plays a role in myogenic differentiation.
