基因名:
CDKN2AIP
产品别名:
CARF; CDKN2AIP; CDKN2A interacting protein; CDKN2A interacting protein; CDKN2A-interacting protein; collaborates/cooperates with ARF (alternate reading frame) protein; collaborator of ARF; 钙反应因子;
背景信息:
CARF was first cloned as a novel binding partner of ARF from a yeast interactive screen. CARF and ARF colocalize in the perinucleolar region and have a collaborative function. In the nucleoplasm, CARF interacts with p53 and enhances its function. The p53 downregulates CARF in a negative feedback regulatory loop and may also involve p53 antagonist HDM2.