基因名：
OTUB1
产品别名：
HSPC263； OTB1； OTU1； OTUB1； OTU deubiquitinase, ubiquitin aldehyde binding 1； OTU deubiquitinase, ubiquitin aldehyde binding 1； ubiquitin thioesterase OTUB1； OTU domain, ubiquitin aldehyde binding 1； OTU domain-containing ubiquitin aldehyde-binding protein 1； OTU-domain Ubal-binding 1； deubiquitinating enzyme OTUB1； otubain-1； ubiquitin-specific protease otubain 1； ubiquitin-specific-processing protease OTUB1； 卵巢肿瘤蛋白1(OTUB1)； 泛素特异性蛋白酶OTB1；
背景信息：
Deubiquitinating enzymes (DUBs) are proteases that posses the ability to cleave ubiquitin chains or the isopeptide bond that conjugates ubiquitin with a substrate. Human cells have approximately 100 DUBs that play important roles in regulating various cellular events. OTUB1 is a member of the ovarian tumor domain family. It is recognized as a K48 ubiquitin chain-specific DUB and can inhibit E2 enzymes, especially Ubc13 (also known as Ube2N), which is known to synthesize K63-linked ubiquitin chains. OTUB1 may also deubiquitinate TRAF3 and -6. This would negatively regulate virus-triggered type I IFN induction.
