基因名：
CCDC88A
产品别名：
APE； GIRDIN； GIV； GRDN； HkRP1； KIAA1212； PEHO； PEHOL； CCDC88A； coiled-coil domain containing 88A； coiled-coil domain containing 88A； girdin； AKT-phosphorylation enhancer； Hook-related protein 1； g alpha-interacting vesicle-associated protein； girders of actin filaments； 磷酸化肌动蛋白结合蛋白Girdin； 肌动蛋白结合蛋白Girdin；
背景信息：
This gene encodes a member of the Girdin family of coiled-coil domain containing proteins. The encoded protein is an actin-binding protein that is activated by the serine/threonine kinase Akt and plays a role in cytoskeleton remodeling and cell migration. The encoded protein also enhances Akt signaling by mediating phosphoinositide 3-kinase (PI3K)-dependent activation of Akt by growth factor receptor tyrosine kinases and G protein-coupled receptors. Increased expression of this gene and phosphorylation of the encoded protein may play a role in cancer metastasis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
