基因名：
DCP1A
产品别名：
HSA275986； Nbla00360； SMAD4IP1； SMIF； DCP1A； decapping mRNA 1A； decapping mRNA 1A； mRNA-decapping enzyme 1A； DCP1 decapping enzyme homolog A； DCP1 decapping enzyme-like protein A； Smad4-interacting transcriptional co-activator； decapping enzyme hDcp1a； putative protein product of Nbla00360； transcription factor SMIF； 脱帽酶1A；
背景信息：
Cleavage of the 5'-cap structure is involved in the major 5'-to-3' and nonsense-mediated mRNA decay pathways. The protein complex consisting of Dcp1 and Dcp2 has been identified as the species responsible for the decapping reaction in Saccharomyces cerevisiae. In nonsense-mediated decay, the human decapping complex, made up of S. cerevisiae homologs hDcp1a and hDcp2, may be recruited to mRNAs containing premature termination codons by nonsense-mediated decay factor (Upf) proteins. hDcp2 specifically hydrolyzes methylated capped RNA to release m(7)GDP, thereby aiding in mRNA degradation. Both hDcp1a and hDcp2 colocalize in the cytoplasm. In addition, hDcp1a interacts with Smad4 forming a complex with TGF Beta and BMP-4. hDcp1a and Smad4 interact directly through a EVH1/WH1 domain on hDcp1a and a proline-rich activation domain on Smad4. Smad4 is essential to nuclear translocation of hDcp1a as deletion of the Smad4-interacting domain (located in the N-terminal 100 amino acids) of hDcp1a eliminates TGF Beta-induced nuclear translocation of hDcp1a.
