基因名：
POGLUT1
产品别名：
C3orf9； CLP46； KDELCL1； KTELC1； LGMD2Z； LGMDR21； MDS010； MDSRP； Rumi； hCLP46； POGLUT1； protein O-glucosyltransferase 1； protein O-glucosyltransferase 1； protein O-glucosyltransferase 1； 9630046K23Rik； CAP10-like 46 kDa protein； KDELC family like 1； KTEL (Lys-Tyr-Glu-Leu) containing 1； KTEL motif-containing protein 1； O-glucosyltransferase Rumi homolog； hRumi； myelodysplastic syndromes relative protein； protein O-xylosyltransferase POGLUT1； x 010 protein； 骨髓增生异常综合征相关蛋白；
背景信息：
CLP46 is a KTEL motif-containing protein that belongs to the CAP10 family. The KTEL motif at the C-terminus of CLP46 is an endoplasmic reticulum (ER) retention signal which localizes the CLP46 protein to the lumen of the ER. CLP46 is thought to promote cell proliferation and is also believed to be involved with hepatic functions. The Drosophila protein rumi, a CAP10 protein and likely similar in function to CLP46, uses glucosylation to act as a Notch signaling regulator. Expressed in varying degrees in most adult tissue, CLP46 is especially abundant in the liver. CLP46 is not expressed in detectable levels in colon, thymus or small intestine. Human CLP46 shares 94% and 91% sequence similarity with its bovine and mouse homologs, respectively.
