基因名：
AKR1B10
产品别名：
AKR1B11； AKR1B12； ALDRLn； ARL-1； ARL1； HIS； HSI； AKR1B10； aldo-keto reductase family 1 member B10； aldo-keto reductase family 1 member B10； aldo-keto reductase family 1 member B10； ARP； SI reductase； aldo-keto reductase family 1, member B10 (aldose reductase)； aldo-keto reductase family 1, member B11 (aldose reductase-like)； aldose reductase-like 1； aldose reductase-like peptide； aldose reductase-related protein； hARP； small intestine reductase； 醛糖还原酶相关蛋白质；
背景信息：
AKR1B10 is also known as aldose reductase-like-1 (ARL-1), small intestine reductase (SI reductase) or aldose reductase-related protein (ARP or hARP). AKR1B10 is found in many tissues but is predominantly expressed in small intestine, colon and adrenal gland. AKR1B10 is an efficient reductase for aliphatic and aromatic aldehydes. It plays a role in steroid metabolism as well as detoxification of aldehydes in digested food, and may be involved in the retinal-retinoic acid signaling pathway. AKR1B10 is prominently overexpressed in non-small cell lung carcinoma and adenocarcinoma. Cigarette smoking is an independent variable responsible for this overexpression. AKR1B10 may play a role regulating cell proliferation and cellular response to carbonyl stress.
