基因名：
TWSG1
产品别名：
TSG； TWSG1； twisted gastrulation BMP signaling modulator 1； twisted gastrulation BMP signaling modulator 1； twisted gastrulation protein homolog 1； twisted gastrulation homolog 1； 扭转原肠胚形成同源物1(TWSG1)； 扭转原肠胚形成同源蛋白1；
背景信息：
Twisted Gastrulation Protein Homolog 1 (TWSG1) is a 22 kDa secreted protein that belongs to the twisted gastrulation protein family. Human TWSG1 is synthesized as a 223 aa precursor that contains a 25 aa signal peptide and a 198 aa mature chain. TWSG1 may be involved in dorsoventral axis formation. TWSG1 seems to antagonize BMP signaling by forming ternary complexes with CHRD and BMPs, thereby preventing BMPs from binding to their receptors.TWSG1 can inhibit BMP activity by binding directly to BMP proteins, and can act the anti-BMP function, partly mediated by cleavage and degradation of CHRD, which releases BMPs from ternary complexes. TWSG1 may be an important modulator of BMP-regulated cartilage development, chondrocyte differentiation and thymocyte development.
