基因名：
TIGAR
产品别名：
C12orf5； FR2BP； TIGAR； TP53 induced glycolysis regulatory phosphatase； TP53 induced glycolysis regulatory phosphatase； fructose-2,6-bisphosphatase TIGAR； TP53-induced glycolysis and apoptosis regulator； fructose-2,6-bisphosphate 2-phosphatase； probable fructose-2,6-bisphosphatase TIGAR； transactivated by NS3TP2 protein； TIGAR蛋白； TP53诱导糖酵解凋亡调节蛋白(TIGAR)；
背景信息：
This gene is regulated as part of the p53 tumor suppressor pathway and encodes a protein with sequence similarity to the bisphosphate domain of the glycolytic enzyme that degrades fructose-2,6-bisphosphate. The protein functions by blocking glycolysis and directing the pathway into the pentose phosphate shunt. Expression of this protein also protects cells from DNA damaging reactive oxygen species and provides some protection from DNA damage-induced apoptosis. The 12p13.32 region that includes this gene is paralogous to the 11q13.3 region. [provided by RefSeq, Jul 2008]
