基因名：
PNPLA2
产品别名：
1110001C14Rik； ATGL； FP17548； PEDF-R； TTS-2.2； TTS2； iPLA2zeta； PNPLA2； patatin like phospholipase domain containing 2； patatin like phospholipase domain containing 2； patatin-like phospholipase domain-containing protein 2； IPLA2-zeta； TTS2.2； adipose triglyceride lipase； calcium-independent phospholipase A2； calcium-independent phospholipase A2-zeta； desnutrin； mutant patatin-like phospholipase domain containing 2； pigment epithelium-derived factor； pigment epithelium-derived factor receptor； transport-secretion protein 2.2； triglyceride hydrolase； 含Patatin样磷脂酶域蛋白2(PNPLA2)； 脂肪甘油三酯脂酶；
背景信息：
Adipose triglyceride lipase (ATGL) may function as a lipase and play a role in the adaptive response to a low energy state, such as fasting, by providing fatty acids to other tissues for oxidation. In addition, decreased expression of desnutrin in obesity models suggests its possible contribution to the pathophysiology of obesity. ATGL catalyzes the initial step in triglyceride hydrolysis in mammalian adipose tissue. ATGL contains a patatin domain common to plant acyl hydrolases. ATGL is highly expressed in adipose tissue of mice and humans. It exhibits high substrate specificity for triacylglycerol and is associated with lipid droplets. Inhibition of ATGL markedly decreases total adipose acyl hydrolase activity. Thus, ATGL and HSL coordinately catabolize stored triglycerides in adipose tissue of mammals.
