基因名:
Slc12a5
产品别名:
KCC2; mKIAA1176; Slc12a5; solute carrier family 12, member 5; solute carrier family 12, member 5; solute carrier family 12 member 5; K-Cl cotransporter 2; electroneutral potassium-chloride cotransporter 2; mKCC2; neuronal K-Cl cotransporter; 神经细胞钾氯离子转运蛋白; 钾氯协同转运蛋白2(KCC2);
背景信息:
K-Cl cotransporters are proteins that lower intracellular chloride concentrations below the electrochemical equilibrium potential. The protein encoded by this gene is an integral membrane K-Cl cotransporter that can function in either a net efflux or influx pathway, depending on the chemical concentration gradients of potassium and chloride. The encoded protein can act as a homomultimer, or as a heteromultimer with other K-Cl cotransporters, to maintain chloride homeostasis in neurons. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Sep 2008]