基因名:
PBXIP1
产品别名:
HPIP; PBXIP1; PBX homeobox interacting protein 1; PBX homeobox interacting protein 1; pre-B-cell leukemia transcription factor-interacting protein 1; hematopoietic PBX-interacting protein; pre-B-cell leukemia homeobox interacting protein 1; 造血PBX;
背景信息:
PBXIP1 is a regulator of pre-B-cell leukemia transcription factors (BPXs) function. It inhibits the binding of PBX1-HOX complex to DNA and blocks the transcriptional activity of E2A-PBX1. PBXIP1 also tethers estrogen receptor-alpha (ESR1) to microtubules and allows them to influence estrogen receptors-alpha signaling.