基因名：
NMRAL1
产品别名：
HSCARG； SDR48A1； NMRAL1； NmrA like redox sensor 1； NmrA like redox sensor 1； nmrA-like family domain-containing protein 1； NmrA-like family domain containing 1； epididymis secretory sperm binding protein； short chain dehydrogenase/reductase family 48A, member 1； NMRAL1蛋白；
背景信息：
HSCARG is a 299 amino acid redox sensor protein that belongs to the NmrA-type oxidoreductase family. Localizing primarily to the cytoplasm and perinuclear region, HSCARG localization to the nucleus may occur with increased intracellular nitric oxide and reduced NADPH/NADP+ ratios. Existing as a homodimer, HSCARG interacts with ASS1, inhibiting ASS1 activity in the presence of low NADPH/NADP+ ratios. HSCARG gets induced by nitric oxide, cGMP and proinflammatory cytokines. The gene encoding HSCARG maps to human chromosome 16p13.3 and mouse chromosome 16 A1. Overexpression of the gene encoding HSCARG results in increased cell viability.
