基因名：
RPTOR
产品别名：
KOG1； Mip1； RPTOR； regulatory associated protein of MTOR complex 1； regulatory associated protein of MTOR complex 1； regulatory-associated protein of mTOR； p150 target of rapamycin (TOR)-scaffold protein containing WD-repeats； raptor； mTOR相关调控蛋白； mTOR调节关联蛋白(RPTOR)； 磷酸化mTOR相关调控蛋白；
背景信息：
mTOR controls cell growth, in part by regulating p70 S6 kinase alpha (p70alpha) and eukaryotic initiation factor 4E binding protein 1 (4EBP1). Raptor is a 150 kDa mTOR binding protein that also binds 4EBP1 and p70alpha. The binding of Raptor to mTOR is necessary for the mTOR-catalyzed phosphorylation of 4EBP1 in vitro, and it strongly enhances the mTOR kinase activity toward p70alpha. Rapamycin or amino acid withdrawal increases, whereas insulin strongly inhibits, the recovery of 4EBP1 and raptor on 7-methyl-GTP Sepharose. Partial inhibition of raptor expression by RNA interference (RNAi) reduces mTOR-catalyzed 4EBP1 phosphorylation in vitro. RNAi of C. elegans raptor yields an array of phenotypes that closely resemble those produced by inactivation of Ce-TOR. Thus, raptor is an essential scaffold for the mTOR-catalyzed phosphorylation of 4EBP1 and mediates TOR action in vivo.
