基因名:
VPS18
产品别名:
PEP3; VPS18; VPS18 core subunit of CORVET and HOPS complexes; VPS18 core subunit of CORVET and HOPS complexes; vacuolar protein sorting-associated protein 18 homolog; VPS18, CORVET/HOPS core subunit; hVPS18; vacuolar protein sorting 18 homolog; vacuolar protein sorting protein 18; 空泡分选蛋白18;
背景信息:
Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene encodes the human homolog of yeast class C Vps18 protein. The mammalian class C Vps proteins are predominantly associated with late endosomes/lysosomes, and like their yeast counterparts, may mediate vesicle trafficking steps in the endosome/lysosome pathway.