基因名:
TRIB3
产品别名:
C20orf97; NIPK; SINK; SKIP3; TRB3; TRIB3; tribbles pseudokinase 3; tribbles pseudokinase 3; tribbles homolog 3; TRB-3; neuronal cell death inducible putative kinase; p65-interacting inhibitor of NF-kappa-B; p65-interacting inhibitor of NF-kappaB; 神经细胞死亡诱导蛋白激酶;
背景信息:
The protein encoded by this gene is a putative protein kinase that is induced by the transcription factor NF-kappaB. The encoded protein is a negative regulator of NF-kappaB and can also sensitize cells to TNF- and TRAIL-induced apoptosis. In addition, this protein can negatively regulate the cell survival serine-threonine kinase AKT1. Differential promoter usage and alternate splicing result in multiple transcript variants. [provided by RefSeq, Jul 2014]